An unusually aggressive clinical behavior in a case of atypical subependymal giant cell astrocytoma

摘要

Sir, Subependymal giant cell astrocytoma (SEGA) is a benign tumor that mostly arises in the wall of the lateral ventricle. Though it has been classified as a low grade, WHO Grade 1 tumor, aggressive lesions with metastasis and intratumoral hemorrhages have been described. High grade features like mitoses, focal necrosis, and endothelial proliferations are distinctly rare, but few cases have been reported in the literature with these unusual findings of high-grade tumor, termed as atypical SEGA.[Despite anaplasia in histology, the clinical behavior of these patients have been benign, same as typical SEGA. A few cases of atypical SEGA may behave aggressively. We report a case of atypical SEGA mimicking malignant glioma with an unusually aggressive clinical course.