Levels of catecholamines, arginine vasopressin and atrial natriuretic peptide in hypotensive extremely low birth weight infants in the first 24 hours after birth.

摘要

BACKGROUND: Extremely low birth weight infants (ELBWI) often suffer from severe hypotension in the early neonatal period. However, few previous studies have ever revealed plasma levels of vasoactive substances which regulate the cardiovascular system in ELBWI. OBJECTIVE: To study plasma levels of vasoactive substances in ELBWI with hypotension during the first 24 h of life. METHODS: 22 ELBWI with hypotension (gestational age 26.4 +/- 1.9 weeks; birth weight 751 +/- 135 g) were involved in the study. After initial volume therapy, the infants were arbitrarily divided into two groups depending on requirement of dopamine dosage: severe hypotension group (SH; dopamine >10 microg/kg/min, n = 9) and mild hypotension group (MH; dopamine