Beneficial effects of intensive insulin therapy in critically ill patients. European Dialysis and Transplant Association - European Renal Association

摘要

Critically ill patients in intensive care units (ICU) for more than a few days have a mortality of approximately 20% world-wide. These critically ill patients, in the absence of a previous diagnosis of diabetes, commonly exhibit stress hyperglycemia and insulin resistance . Many of these critically ill patients die of multiorgan dysfunction (MOD) and sepsis. Since stress hyperglycemia has been shown to associate with impaired polymorphonuclear neutrophil function and bactericidal activity , the question arose whether lowering of blood glucose in critically ill patients would decrease morbidity and mortality.