Can a single growth hormone level be used to assess disease activity after treatment of acromegaly?

摘要

Measurement of the nadir growth hormone (GH) level during an oral glucose tolerance test (OGTT) is conventionally used to monitor disease activity after treatment of acromegaly. Nonetheless, the need to collect multiple blood samples represents a potential drawback of this test.To determine whether measurement of the GH level in a basal blood sample taken before administration of oral glucose can be used as a surrogate for the nadir GH level.