Which criteria best support the diagnosis of Wl sporadic Creutzfeldt-Jakob disease?

摘要

Between 1993 and 2003, nine cases of VV1 sCJD were reported to the CJD Surveillance Unit in Gottingen, Germany (eight men and one woman). Diagnoses were confirmed by molecular analysis of the prion protein (PrP) gene and by western blot analysis of frozen brain tissue. All patients underwent electroencephalography (EEG; carried out over a median of 7 months after onset), fluid-attenuated inversion recovery (FLAIR) and T2 MRI (carried out after a third of the overall disease duration), and lumbar puncture to evaluate 14-3-3 protein levels in the cerebrospinal fluid (CSF; carried out after a median duration of 7 months after onset).