BETWEEN BEDSIDE AND BENCH Taking on Toll-like receptors-Toll-free immunity?

摘要

It has been a decade since immunologists discovered a key component of innate immunity: Toll-like receptors (TLRs), which trigger innate immune responses by detecting pathogens and their products. An explosion of basic and applied research has made TLR biology central to immunology and has led to a general view that the detection of pathogens by TLRs initiates the mobilization of host defenses against most, if not all, infectious agents#