Bone: Use of bisphosphonates in children-proceed with caution.

Marini JC

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Bone: Use of bisphosphonates in children-proceed with caution.

机译：骨：儿童慎用双膦酸盐。

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A clinical review of studies on bisphosphonate therapy for pediatric osteoporosis has revealed that they increase BMD, but whether they also improve fracture rates or functions of daily life is unclear. Can the findings of this clinical review help inform clinicians whether, when and how to use these agents in children?

机译：对双膦酸盐治疗小儿骨质疏松症的研究的临床研究表明，它们会增加BMD，但是尚不清楚它们是否还能改善骨折率或日常生活功能。此临床检查的结果能否帮助临床医生了解是否，何时以及如何在儿童中使用这些药物？

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《Nature reviews. Endocrinology》 |2009年第5期|共3页
作者
Marini JC;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Bone: Use of bisphosphonates in children-proceed with caution. [J] . Marini JC Nature reviews. Endocrinology . 2009,第5期

机译：骨：儿童慎用双膦酸盐。
2. Msx-1 is suppressed in bisphosphonate-exposed jaw bone analysis of bone turnover-related cell signalling after bisphosphonate treatment. [J] . Wehrhan F, Hyckel P, Amann K, Oral diseases . 2011,第4期

机译：在双膦酸盐处理后骨质周转相关细胞信号传导的双膦酸盐暴露的钳口骨分析中抑制了MSX-1。
3. Msx-1 is suppressed in bisphosphonate-exposed jaw bone analysis of bone turnover-related cell signalling after bisphosphonate treatment. [J] . Wehrhan F, Hyckel P, Amann K, Oral diseases . 2011,第4期

机译：在双膦酸盐处理后骨质周转相关细胞信号传导的双膦酸盐暴露的钳口骨分析中抑制了MSX-1。
4. Interaction between nanocrystalline apatites as models of bone mineral and bisphosphonates molecules in bone cells environment [C] . Patricia PASCAUD, Reine BAREILLE, Chantal BOURGET, . 2012

机译：纳米晶磷灰石之间作为骨矿物质模型和双膦酸盐分子在骨细胞环境中的相互作用
5. Bisphosphonate-Modified Nanoparticles as Drug Delivery Systems for Bone Diseases [D] . Wang, Guilin 2011

机译：双膦酸酯修饰的纳米粒子作为骨疾病的药物输送系统
6. Differential Action of the Bisphosphonates (3-Amino-1-Hydroxypropylidene)-11-Bisphosphonate (APD) and Disodium Dichloromethylidene Bisphosphonate (Cl2MDP) on Rat Macrophage-mediated Bone Resorption In Vitro [O] . Pieter H. Reitsma, Steven L. Teitelbaum, Olav L. M. Bijvoet, 1982

机译：双膦酸酯（3-氨基-1-羟丙基）-11-双膦酸酯（APD）和二氯亚甲基双膦酸钠（Cl2MDP）对大鼠巨噬细胞介导的骨吸收的体外作用
7. Differential Action of the Bisphosphonates (3-Amino-1-Hydroxypropylidene)-1,1-Bisphosphonate (APD) and Disodium Dichloromethylidene Bisphosphonate (Cl2MDP) on Rat Macrophage-mediated Bone Resorption In Vitro [O] . Reitsma, Pieter H., Teitelbaum, Steven L., Bijvoet, Olav L. M., 1982

机译：双膦酸酯（3-氨基-1-羟丙基）-1,1-双膦酸酯（APD）和二氯亚甲基双膦酸钠（Cl2MDP）对大鼠巨噬细胞介导的骨吸收的体外作用

Bone: Use of bisphosphonates in children-proceed with caution.

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