Direction-selective ganglion cells (DS cells) in the retina respond to stimuli that move in a particular direction and not to stimuli that move in the opposite (null) direction. This direction sensitivity requires asymmetric inhibitory input from starburst amacrine cells, but how and when this asymmetric wiring is established has remained elusive. Now, two papers published in Nature show that inhibitory input from starburst cells is initially symmetrical but reorganizes and becomes asymmetrical before eye opening, independently of neural activity.
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