Neurodegenerative disease: The pyroglutamylated seed.

摘要

Pyroglutamylated (pE) forms of amyloid-beta (Abeta) have been proposed to have a role in the pathogenesis of Alzheimer's disease, but the underlying mechanism is unclear. A new study shows that Abeta_(3(pE)-42) can form short oligomers with Abeta_(1-42) -which is widely implicated in Alzheimer's disease pathogenesis - and that these arrays are more cytotoxic to cultured neurons than oligomers of Abeta_(1-42) alone.