Epigenetics: Histone methyltransferase mutations promote leukaemia

摘要

Recent sequencing studies of human cancers have identified tumour-specific mutations in genes encoding proteins that function in chromatin regulation, although their functional importance has not always been clear. A study by Zhu et al. has identified mutations in the histone-lysine N-methyltransferase SETD2 and has shown that these mutations cooperate with other genetic aberrations in leukaemia.