THE IKK NF-(kappa)B SYSTEM: A TREASURE TROVE FOR DRUG DEVELOPMENT

摘要

Nuclear factor-KB (NF-(kappa)B)/Rel transcription factors have been suspected since their discovery to play a pivotal role in chronic and acute inflammatory diseases. It now seems that aberrant regulation of NF-(kappa)B could also underlie autoimmune diseases and different types of cancer. Recently, NF-(kappa)B and the signalling pathways that regulate its activity have become a focal point for intense drug discovery and development efforts. Given the large number of major ailments in which aberrant regulation of NF-(kappa)B has been observed or is suspected, such efforts seem well justified. This review will discuss recent progress in the development of drugs that inhibit NF-(kappa)B activation, and consider their potential applications in inflammatory and autoimmune diseases, as well as cancer.