DNA damage: In at the beginning.

摘要

Not all regions of the genome replicate equally well. Regions known as common fragile sites (CFSs) are present in genomic areas that are characterized by a closed chromatin structure and that replicate late in S phase. However, recent research in mouse B cells indicates that, in addition to these late replicating CFSs, there are early replicating fragile sites (ERFSs) that could contribute to the genetic translocations and copy number alterations that are often seen in B cell lymphomas.