Benefits of vascular normalization are dose and time dependent - Letter

摘要

Arjaans and colleagues reported that treatment with the anti-VEGF antibody bevacizumab hampers antibody uptake in an ectopic xenograft model of human ovarian cancer in mice (1). They found that bevacizumab decreased vessel number and increased pericyte coverage and concluded that treatment-induced normalization is detrimental for antibody delivery. This conclusion is not supported by their data and is in disagreement with the existing literature (2-4).