WAYS OF MINIMIZING THE TOXICITY AND INCREASING THE SELECTIVITY OF DRUGS

摘要

Problems of synthesis of carbohydrate analogs of nitrosomethyl urea are considered.It is shown that toxicity and selective action of carbohydrate analogs of nitrosomethyl urea depend heavily on the nature of a monosaccharide carrier of a cytoxic agent.Many drugs are highly toxic and have a number of side effects,which prevents their extensive use in medicine.However,it is known that incorporation of carbohydrate residues into the structure of biologically active compounds causes a dramatic decrease in their toxicity and this makes it possible to recommend the method of glycosylation of a physiologically active compound(or its individual fragments)at a glycoside site of sugars as a possible way of producing low-toxicity drugs.