Pharmacokinetic Study of Original and Generic Levofloxacin Tablets

摘要

The comparative pharmacokinetic study of the generic levofloxacin tablets (500 mg) produced at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences and the original levofloxacin tablets (500 mg) Tavanic produced by Sanofi Vintron Industry (France) has been performed. The limit of quantitative determination was 25 ng/mL. The pharmacokinetic parameters of the compared preparations have been calculated. The relative bioavailability of the generic drug has been determined (108.6 + 25.6%).