Reply: Bilateral globus pallidus internus deep brain stimulation after bilateral pallidotomy in a patient with generalized early-onset primary dystonia

摘要

We appreciate the letter and the interest shown by Drs. Wain and Jancovic in calling attention to the fact that other patients with dystonic symptoms may be waiting for additional treatment. Dozens of patients with generalized dystonia have undergone ablative stereotactic neurosurgery throughout the years. Historically, thalamotomy and pallid-otomy (often bilateral) have been the major procedures performed in patients with dystonia.Although significant improvements in dystonic symptoms have typically been reported at short-term and intermediate-term follow-up visits after ablative procedures, the disease often progresses and the patients' conditions deteriorate in the long-term. Patients who had previously undergone these procedures are now seeking new treatment possibilities and may find the development of new deep brain stimulation (DBS) targets helpful.