Can We Estimate Late-Onset Sepsis by Serial Methemoglobin Levels? An Observational Study in Preterm Neonates

摘要

Objective: To assess serial methemoglobin (MetHb) levels in preterm infants as a possible diagnostic method for late-onset sepsis (LOS). Methods: Preterm infants were assigned into two groups: those with culture-proven LOS and controls. Serial MetHb levels were measured. Results: The MetHb values of the LOS group were found to be significantly increased (p 1.75, optimized for a sensitivity of 81.9 and specificity of 90. After antimicrobial therapy, MetHb values were found to decrease significantly (p 2 (p 2 is associated with LOS mortality.