Pharmacologically directed cell disposal: Labeling damaged cells for phagocytosis as a strategy against acute pancreatitis

摘要

Apoptosis is the main mechanism of programmed cell deletion in multicellular organisms and proceeds with typical changes in cell morphology that accompany cell death and clearance. Necrosis, on the other hand, is a form of traumatic cell death featuring cell swelling, disruption of plasma membrane and the membranes of the organelles, and release of cytosolic constituents (Box 1). In contrast to apoptosis, which often provides beneficial effects to the organism, necrosis is almost always detrimental. Acute pancreatitis (AP) is a localized inflammation in the pancreas that occasionally evolves into a systemic life-threatening disease.