Starting from mechanistic studies of alkylnitrosoureas, the serendipitous liaison between univeisity researchers and medicinal chemists culminated in the anti-tumor drug temozolomide, today an essential element in the aisenal of anti-proliferative, DNA-alkylating agents in the treatment of malignant glioma. The application of temozolomide, alone and in combination, continues to expand.
展开▼
