Activity of rheumatoid arthritis correlates with oral inflammatory burden

摘要

To study oral health in patients with rheumatoid arthritis (RA) with emphasis on disease activity and treatment of RA. In this prospective cohort study 81 RA patients 53 early untreated RA (EURA) and 28 chronic RA (CRA) patients with inadequate response to synthetic disease modifying antirheumatic drugs (DMARDs), underwent rheumatological Disease Activity Score (28-joint) DAS28 and dental examinations Total Dental Index (TDI), Decayed Missing Filled Teeth (DMFT) and Decayed Missing Filled Surfaces (DMFS). For controls, 43 volunteers were examined. After the examinations, EURA patients started treatment with synthetic DMARDs, oral and intra-articular glucocorticoids. CRA patients were candidates for biological DMARDs. The patients were re-examined mean 16 months later. Results were analyzed with descriptive statistics and logistic regression. TDI was higher in both RA groups at baseline compared to controls EURA: 2 (2-3); CRA: 2 (1-3); controls 1 (1-3), p = 0.045. DMFT r(s) 0.561 (p = 0.002) and DMFS r(s) 0.581 (p = 0.001) associated with DAS28 at baseline in CRA patients. After follow-up, DAS28 associated positively with DMFT r(s) 0.384 (p = 0.016) and DMFS r(s) 0.334 (p = 0.038) in EURA patients; as well as in CRA patients DMFT r (s) 0.672 (p = 0.001), DMFS r(s) 0.650 (p = 0.001). RA patients already in the early phase of the disease had poorer oral health compared to controls. The caries indices associated with the activity of RA in both patient groups. Oral status may thus contribute to the development and further relate to the activity of RA.