首页> 外文期刊>Mini reviews in medicinal chemistry >Designing a pronucleotide stratagem: lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines.
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Designing a pronucleotide stratagem: lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines.

机译:设计前核苷酸策略:抗癌和抗病毒嘧啶氨基酸氨基磷酸酯的课程。

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摘要

Phosphoramidate pronucleotides have proven to be an effective strategy for the intracellular delivery of nucleoside 5'-monophosphates. This review will summarize our efforts to understand the in vitro and in vivo behavior of phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT), 3'-fluoro-3'-deoxythymidine (FLT) and 5-fluoro-2'-deoxyuridine (FUdR). Insights drawn from these studies have proved valuable for the future design of phosphoramidate-based pronucleotides.
机译:磷酸氨基磷酸酯原核苷酸已被证明是细胞内递送核苷5'-单磷酸的有效策略。这篇综述将总结我们为了解3'-叠氮基3'-脱氧胸苷(AZT),3'-氟-3'-脱氧胸苷(FLT)和5-氟-2的氨基磷酸单酯的体外和体内行为所做的努力。 -脱氧尿苷(FUdR)。从这些研究中得出的见解已被证明对未来基于氨基磷酸酯的前核苷酸的设计有价值。

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