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High aspect ratio tapered hollow metallic microneedle arrays with microfluidic interconnector

机译:具有微流体互连器的高深宽比锥形中空金属微针阵列

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摘要

We present a novel microfabrication method for a tapered hollow metallic microneedle array and its complete microfluidic packaging for drug delivery and body fluid sampling applications. Backside exposure of SU-8 through a UV transparent substrate was investigated as a means of fabricating a dense array of tall (up to 400 μm) uniformly tapered SU-8 pillar structures with angles in the range of 3.1-5° on top of the SU-8 mesa. Conformal electroplating of metals on top of the array of the tapered SU-8 pillars, lapping of the tip of the metallic microneedles with planarizing polymer, and removal of the SU-8 sacrificial layers resulted in an array of tapered hollow metallic microneedles with a fluidic reservoir on the backside. A microfluidic interconnector assembly was designed and fabricated using SU-8 and conventionally machined PMMA in a way that it has a male interconnector, which directly fits into the fluidic reservoir of the microneedle array at one end and the other male interconnector, which provides fluidic interconnection to external devices at the other end. The fluid flow rate was measured and it showed 0.69 μL/s. per microneedle when the pressure of 6.89 KPa (1 psi) was applied.
机译:我们提出了一种新颖的微细加工方法,用于锥形中空金属微针阵列及其用于药物输送和体液采样应用的完整微流体包装。研究SU-8通过UV透明基板的背面暴露,以制造高密度(高达400μm)均匀锥形SU-8柱结构的致密阵列,该结构的顶角在3.1-5°范围内。 SU-8台面。在锥形SU-8柱阵列的顶部进行保形的金属电镀,用平面化聚合物研磨金属微针的尖端,并去除SU-8牺牲层,从而形成带有流体的锥形中空金属微针阵列背面有水库。使用SU-8和常规加工的PMMA来设计和制造微流体互连器组件,其方式是:它具有凸形互连器,该凸形互连器直接安装在一端的微针阵列的流体储器中,而另一凸形互连器提供流体互连。到另一端的外部设备。测量流体流速,其显示为0.69μL/ s。当施加6.89 KPa(1 psi)的压力时,每个微针。

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