Influence of structural, textural and surface properties of mesostructured silica and aluminosilicate carriers on aminoglycoside uptake and in vitro delivery

摘要

This work assessed the influence of structural, textural and surface features of mesostructured silica and aluminosilicate carriers on aminoglycosides encapsulation and in vitro release. A series of pure and functionalized mesostructured silica, as well as aluminosilicates, which belong to MCM-41, MCM-48 and SBA-15 classes, and two aminoglycosides with related structure, amikacin and kanamycin as biologically-active molecules were employed in order to prepare drug delivery systems. No significant toxicity of studied mesoporous carriers on MEF cells after 72 h of continuous exposure to 100 mu g/mL nanoparticles was noticed. The mesostructured supports and amikacin- and kanamycin-based hybrid samples were characterized by small- and wide-angle XRD, FT-IR spectroscopy, thermogravimetric analysis, and N-2 sorption isotherms. The uptake values for all amikacin-based hybrids are higher than those for kanamycin counterparts. Moreover, the first antibiotic can be loaded on functionalized (with 3-aminopropyl or methyl groups) SBA-15-type materials, unlike the last drug. Amikacin loaded into the mesopores of AlSBA-15 and SBA-15 vehicles exhibited a slower delivery rate than from MCM-48 and functionalized SBA-15 materials. Different than amikacin-based hybrids, kanamycin loaded on aluminosilicates (AlMCM-41 and AlSBA-15) caused faster delivery, the highest value of drug cumulative release at 24 h being obtained for AlMCM-41 support. (C) 2014 Elsevier Inc. All rights reserved.