Maturation of the cerebellar Purkinje cells

摘要

The effects of thyroid deficiency are tested on the cerebellar Purkinje cells spontaneous firing (simple spikes) of young rats. Hypothyroidism is obtained by giving the mothers Propylthiouracile (P.T.U.) during the first postnatal month. Animals are studied between 5 days after birth and the middle of the 3rd postnatal month by comparison with controls: normally maturing rats and P.T.U. young rats also submitted to a daily administration of 2 micrograms of D.L. Thyroxine during the first postnatal month. Two experimental conditions are used: rats anaesthetized with Nembutal and rats only locally analgesied, the 2 preparations being curarized. It is shown that: