Expression of alpha estrogen receptors in the neurons of the hippocampus in male rabbits

摘要

The subject of the present paper was to show presence of a estrogen receptors in neurons of hippocampal formation in adult male rabbits. Estrogen hormones perform a crucial role in sex differentiation and reproduction, but also influence a number of brain functions not connected with reproduction. Clinical examinations prove estrogens' influence on cognitive processes, memory, mood, emotional behavior, pain sensation, mobility, state of balance. Estrogens have a neuroprotecting action, they influence neurons' length of life and as a result of that, degenerative diseases of the nervous system connected with age. The examinations prove that estrogen substitutive therapy decreases the development rate of Alzheimer and Parkinson's disease, multiple sclerosis, osteoporosis, depression and migraines. It is thought that estrogen administration in the case of these diseases diminishes intensification of symptoms. In relation to this, it is crucial to learn the mechanisms of hormones' activity and determine the localization of their receptors. The obtained results indicate that estrogen hormones can influence cognitive processes, learning and memory. Learning the mechanisms of estrogens' activity and determining which brain structures they influence can be helpful in treating neurodegenerative diseases. In adult rabbit males a estrogen receptors occur in neurons of the hippocampus in cytoplasm as well as cell nucleus. In the examined regions cytoplasmic and cytoplasmic-nuclear reaction predominates.