A FULLERENE - BIHETEROCYCLIC ENTITY CHEMOTHERAPEUTIC: SYNTHESIS, CHARACTERIZATION AND STUDY of BIOLOGICAL ACTIVITY

摘要

A few novel s-triazine based thiazolidinones bearing fullerene moiety have been synthesized. The fiillerene derivatives mentioned here was synthesized using 1, 3 dipolar cycloaddition reaction via imminium salt formation using sarcosine. The thiazolidinones which were attached to fiillerene in turn were prepared by condensation of melamine based compounds to nitro substituted aromatic aldehydes which was followed by cyclisation using thioglycolic acid. These thiazolidinones and their fiillerene linked chemotherapeutics were then purified, characterized by elemental analysis, FT-IR, ~1HNMR, ~(13)CNMR and FAB-MS and then tested for their antibacterial, antifungal and anti-HTV activities. The change in activity on attachment of fiillerene has been observed.