Synthesis of new oxadiazole derivatives as anti-inflammatory, analgesic, and antimicrobial agents

摘要

In search of pharmalogically active molecules in the class of oxadiazoles, the present article deals with the synthesis of 5-(5'-fluoro-2'-methoxybiphenyl-3-yl)-l,3,4-oxadiazol-2(3if)-one 2 from its hydrazide analog 1. The compound 2 was regioselectively N-alkylated with alkyl halides and produced the compounds 3a-f. Compound 3f was further functionalized with substituted benzenesulfo-nyl chlorides to give compounds 3g-j. The synthesized compounds were characterized by elemental and spectral analysis. Newly synthesized compounds were tested for their in vivo anti-inflammatory, analgesic, and in vitro antimicrobial activities. The compounds 3a-c were found to have promising anti-inflammatory and analgesic activities. Compounds 3b, 3f, and 3g showed significant antibacterial and antifungal activities.