Plant Natural Products as Potential Modulators of the Transcription Factor NF-kappaB

摘要

Nuclear factor-kappaB (NF-kappaB) is an inducible transcription factor which plays important role in the regulation of the immune, inflammatory and carcinogenic responses. Partial NF-kappaB activation is necessary for normal cell survival and immunity; however the deregulated NF-kappaB expression is associated with cancer development, metastasis, and in several inflammatory disorders with a resistant phenotype and poor prognosis. Therefore, NF-kappaB has become an interesting target for drug discovery and several natural and synthetic products have been screened for their ability to inhibit NF-kappaB pathway. This review surveys the plant natural products with significant NF-kappaB inhibitory activity focusing on their potential mechanism of actionand their implications for cancer therapy.