Split-field vs extended-field intensity-modulated radiation therapy plans for oropharyngeal cancer: Which spares the larynx? Which spares the thyroid?

摘要

Radiation of the low neck can be accomplished using split-field intensity-modulated radiation therapy (sf-IMRT) or extended-field intensity-modulated radiation therapy (ef-IMRT). We evaluated the effect of these treatment choices on target coverage and thyroid and larynx doses. Using data from 14 patients with cancers of the oropharynx, we compared the following 3 strategies for radiating the low neck: (1) extended-field IMRT, (2) traditional split-field IMRT with an initial cord-junction block to 40 Gy, followed by a full-cord block to 50 Gy, and (3) split-field IMRT with a full-cord block to 50 Gy. Patients were planned using each of these 3 techniques. To facilitate comparison, extended-field plans were normalized to deliver 50 Gy to 95% of the neck volume. Target coverage was assessed using the dose to 95% of the neck volume (D-95). Mean thyroid and larynx doses were computed. Extended-field IMRT was used as the reference arm; the mean larynx dose was 25.7 +/- 7.4 Gy, and the mean thyroid dose was 28.6 +/- 2.4 Gy. Split-field IMRT with 2-step blocking reduced laryngeal dose (mean larynx dose 15.2 +/- 5.1 Gy) at the cost of a moderate reduction in target coverage (D-95 41.4 +/- 14 Gy) and much higher thyroid dose (mean thyroid dose 44.7 +/- 3.7 Gy). Split -field IMRT with initial full-cord block resulted in greater laryngeal sparing (mean larynx dose 14.2 +/- 5.1 Gy) and only a moderately higher thyroid dose (mean thyroid dose 31 +/- 8 Gy) but resulted in a significant reduction in target coverage (D-95 34.4 +/- 15 Gy). Extended -field IMRT comprehensively covers the low neck and achieves acceptable thyroid and laryngeal sparing. Split-field IMRT with a full-cord block reduces laryngeal doses to less than 20 Gy and spares the thyroid, at the cost of substantially reduced coverage of the low neck. Traditional 2-step split -field IMRT similarly reduces the laryngeal dose but also reduces low-neck coverage and delivers very high doses to the thyroid. (C) 2016 Published by Elsevier Inc. on behalf of American Association of Medical Dosimetrists.