Hyperpigmentation in Laugier-Hunziker syndrome.

摘要

A 60-year-old nonsmoking Chinese woman presented with a 40-year history of progressive blackish pigmentation of her tongue, oral mucosa and lips (Figure 1A; Appendix 1, available at www.cmaj.ca/lookup /suppl/doi:10.1503/cmaj.H0211/-/DCl). In addition, she had a 10-year history of longitudinal pigmented bands on parts of her fingernails (Figure IB). There was no relevant drug history, and no other family members were affected. Histology of the lesions of the lower lip showed a substantial increase of melanin in the basal keratinocytes but no increase in the number of melanocytes. Serum cortisol and adrenocorti-cotropic hormone levels were within normal limits. The patient underwent an upper gastrointestinal study, barium enema and colonoscopy, which showed no evidence of polyps. A diagnosis of Laugier-Hunziker syndrome was made. In follow-up over the next five years, an increasing number of pigmented macules was noted.