Synthesis and Characterization of a Multi-Sensitive Crosslinked Injectable Hydrogel Based on Pluronic

摘要

This paper reports the construction of a novel multi-sensitive chemically crosslinked injectable hydrogel with strong mechanical strength by modifying Pluronic F127 responsive against temperature, pH and redox potential. Crosslinked polymer between benzaldehyde grafted Pluronic (P-A) and amine end capped Pluronic having disulfide linkage (P-B) have been synthesized and characterized with 1H NMR spectroscopy and GPC. The hydrogel under physiological conditions significantly altered sol-gel transition behaviors with much lower critical gelation concentrations and temperatures, compared to Pluronic hydrogels. The rheological characterization demonstrated that the moduli of the hydrogels were able to be tuned depending on molecular weight as well as pH, redox and temperature conditions. A novel multi-sensitive chemically crosslinked injectable hydrogel has been synthesized based on Pluronic F127. The synthesized polymer forms a stable hydrogel at physiological condition bearing disulfide bonds and benzoic imine bonds within its structure which can be cleaved at higher concentration of DTT and lower pH respectively. Various experiments have been performed to investigate the claimed properties of the synthesized polymer.