首页>
外国专利>
INJECTABLE THERMOSENSITIVE PLURONIC DERIVATIVE HYDROGELS WITH HIGH BIODEGRADABILITY AND BIOCOMPATIBILITY FOR TISSUE REGENERATION AND PREPARATION METHOD THEREOF
INJECTABLE THERMOSENSITIVE PLURONIC DERIVATIVE HYDROGELS WITH HIGH BIODEGRADABILITY AND BIOCOMPATIBILITY FOR TISSUE REGENERATION AND PREPARATION METHOD THEREOF
展开▼
机译:具有高生物可降解性和生物相容性的可注射的热敏性多价衍生水合物,用于组织再生及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a thermosensitive pluronic derivative hydrogel for tissue regeneration in which a biodegradable polymer is introduced at one end or both ends of a pluronic polymer, a methacryloxyethyl trimellitic acid anhydride is conjugated to the biodegradable polymer, and a physiologically active substance is fixed to the methacryloxyethyl trimellitic acid anhydride, as well as a method for the preparation thereof. The pluronic derivative hydrogel according to the present invention exhibits high biodegradability due to the introduction of a biodegradable polymer while still maintaining the themosensitivity of the pluronic polymer itself and shows good biocompatibility owing to the coupling with a physiologically active substance capable of improving cell adhesion, proliferation and differentiation. Therefore, the pluronic derivative hydrogel according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs.
展开▼