Global financial challenge: opportunities for strengthening R&D research in targeted drug delivery.

摘要

Today, the pharmaceutical industry is facing an unprecedented challenge as a result of the significant increase in annual R&D costs along with a declining investment market for pharmaceutical research and a faster rise in the rate of inflation. It has been estimated that as many as 10,000 molecules are screened and tested for every one drug candidate that successfully enters the market [101], and only one in three marketed drugs is able to recoup its development costs. Even some post-marketed drugs have to be withdrawn due to concerns regarding lack of efficacy or undesirable side effects; one example is Merck's non-steroidal anti-inflammatory