Effects of different antiretroviral agents on cerebral function in HIV-infected individuals

摘要

Since the advent of effective antiretroviral therapy, the incidence of severe HIV-associated brain disease has declined dramatically; however, more subtle forms of cerebral impairment, known as HIV-associated neurocognitive disorders, are becoming increasingly recognized. Some of the risk factors for this impairment are well described and include nadir CD4- cell count. However, the effects of differdnt a nti retroviral agents on cerebral function are only beginning to be unraveled. Overall, there areclear beneficial effects on neurocognitive function from a nti retroviral therapy. Recent data suggest that some antiretroviral agents have more potent effects on improving cerebral function, whereas other antiretroviral agents may even be associated with direct cerebral toxicities.