Gastroesophageal reflux disease (GERD) affects approximately 40% of the US population on a monthly basis and 10% daily (Am J Dig Dis 1976;21:953-956). A majority of heartburn sufferers also report nocturnal GERD symptoms (Arch Intern Med 2001:45-52). Because the definition of nocturnal heartburn has not been standardized, this term has included the presence of heartburn symptoms occurring after dinner, GERD symptoms experienced when lying down to initiate sleep, heartburn causing nocturnal arousals, and waking up in the mornings with acid regurgitation (Clin Gastroenterol Hepatol 2009;7:372-378). The presence of nocturnal heartburn has been linked to impaired quality of life, more severe GERD symptoms, and reduction of work productivity (Value Health 2002;5:106-113).
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机译：胃食管反流病（GERD）每月影响约40％的美国人口，每天影响10％（Am J Dig Dis 1976; 21：953-956）。大多数胃灼热患者还报告了夜间GERD症状（Arch Intern Med 2001：45-52）。由于夜间胃灼热的定义尚未标准化，因此该术语包括晚餐后出现胃灼热症状，躺下以开始睡眠时出现的GERD症状，引起夜间唤醒的胃灼热以及早晨因酸反流而醒来（临床Gastroenterol Hepatol 2009; 7：372-378）。夜间烧心的存在与生活质量下降，更严重的GERD症状和工作效率降低有关（Value Health 2002; 5：106-113）。
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