Trial finds administering pravastatin early after symptom onset does not improve outcomes in people with acute coronary syndromes

摘要

In people with acute coronary events, the effect of administering statins early after symptom onset remains uncertain. The Pravastatin in Acute Coronary Treatment (PACT) study assessed the effects of administering pravastatin within 24 hours of symptom onset in people with unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction. The primary endpoint was a composite of death, recurrence of myocardial infarction, or readmission to hospital for unstable angina within 30 days.