Flavonoids as dietary regulators of nuclear receptor activity.

摘要

Research into interactions between dietary flavonoids and nuclear receptors are reviewed, with particular reference to their impact on occurrence of metabolic diseases. Aspects considered include: types of nuclear receptors; nuclear receptors and pharmaceutical targets (oestrogen receptor, peroxisome proliferator-activated receptor, farnesoid X receptor, liver X receptor, pregnane X receptor, hepatocyte nuclear factor 4 alpha); flavonoids as dietary nuclear receptor regulators (flavanones, flavones, flavanols, flavonols, isoflavones, anthocyanins); other herbal substances; and flavonoid bioavailability and delivery (flavonoid-dextran complexes, amorphous solid dispersion).