Rapid onset of multifocal human papillomavirus 72-associated oral intraepithelial neoplasia in a human immunodeficiency virus-infected patient.

摘要

Sir, Human papillomavirus (HPV) -associated neoplasms and their precursor lesions appear in excess among patients with human immunodeficiency virus (HIV) and AIDS. It remains obscure if the increased incidence of these neoplasms reflects an increased HPV exposure, a decreased HPV clearance, a high prevalence of other cofactors, or a genuine role of HIV-related immunosuppression in HPV-induced carcinogenesis. HIV-infected men who have sex with men (MSM) have a drastically increased risk for anal cancer. In several studies, anal HPV infections were detected in up to 93% of HIV-positive MSM and a high prevalence of high-grade anal dysplasia has been leported. So far, HPV-related lesions of the oral mucosa have been reported occasionally in HIV-infected patients. The data concerning the incidence of these lesions in the era of highly active antiretroviral therapy (HAABT) are conflicting.