Pharmacokinetic interaction between nevirapine and darunavir with low-dose ritonavir in HIV-1 -infected patients

摘要

AIM:To investigate the pharmacokinetic interaction between darunavir/ritonavir (DRV/r) and nevirapine (NVP) in 19 HIV-infected patients.METHODS:An open-label, randomized, crossover study. Patients received Treatment A [NVP 200 mg b.i.d. plus >=2 nucieosideucleotide reverse transcriptase inhibitors (NRTIs)] and Treatment B [A plus DRV/r 300/100 mg b.i.d. (DRV oral solution)] or Treatment B2 [A plus DRV/r 400/100 mg b.i.d. (DRV tablet)] in two 14-day sessions.RESULTS:Mean NVP AUC_(12h) increased by 27% [least square means ratio 1.27 (95% confidence interval 1.02,1.58)]. Mean DRV and ritonavir exposures were similar to historical data. Co-administration was well tolerated.