Organocatalytic Enantioselective Friedel-Crafts Reaction of Naphthol with P,y-Unsaturated a-Keto Esters

摘要

The chromane and benzopyrane structures are present as a characteristic structural motif in a large number of natural products that possess a broad array of biological activities such as antimicrobial, antiviral, antitumor, and central nerve system activity. Although many synthetic methods for these compounds have been reported, the enantioselective construction of this chiral scaffold has been rarely explored. The Friedel-Crafts (FC) alkylation is important reaction for the formation of C-C bonds. The asymmetric FC reaction can afford enantiomerically enriched alkylated arene products. A large number of effort has been devoted to the development for catalytic enantioselective FC reaction of arenes to a,p-unsaturated carbonyl compounds using chiral metal complexes as well as organocatalysts.