A Concise and Rapid Approach to the Marine Natural Product Streptochlorin and its Analogues

摘要

The rich chemical diversity of marine life is the inexhaustible source of drug pipeline. Over the last few decades, great strides have been made in our understanding of marine natural products largely due to dramatic advances in the fields of analytical technology, spectroscopy, synthetic chemistry, and high-throughput screening. Nevertheless, it remains elusive how to secure a supply of rare marine natural products to ensure further study for their biomedical application. Consequently it was driven to develop innovative methods including aquaculture, semi-synthesis, and chemical synthesis to ameliorate the material supply problem. Although the chemical synthesis of natural products is still far from being a mature or applied science, it is an important and reliable tool to attain a target natural product and its analogues for further systematic investigation.