Route to Benzimidazol-2-onesvia Decarbonylative RingContraction of Quinoxalinediones: Application to the Synthesis ofFlibanserin A Drug for Treating Hypoactive Sexual Desire Disorderin Women and Marine Natural Product Hunanamycin Analogue

摘要

A simple and practical method to access a variety of benzimidazol-2-ones is reported here. A series of N-alkyl-substituted benzimidazol-2-ones were synthesized by decarbonylative ring contraction starting from corresponding quinoxalinediones for the first time. The utility of the method has been demonstrated by synthesizing recently approved controversial drug flibanserin (Addyi) and a urea analogue of marine antibiotic natural product hunanamycin-A.