Beliefs disease (BD) is a systemic and chronic inflammatory disorder which mainly involves mucocutaneous, ocular, vascular, gastrointestinal, and/or central nervous system organs in association with some genetic background as the intrinsic factors. Generally, the disease starts with oral recurrent aphthous stomatitis (RAS) in young-aged generation and develops to the systemic recurrent inflammation. BD patients are considered to be mainly distributed from the countries around the Mediterranean, old Silk-Road, and Korea to Japan. Historically, there was the antiquity description by Hippocrates and the disease was precisely reported by Turkish dermatologist, Hulusi Behcet, as a trisymptom complex in 1937. BD pathogenesis is still obscure and classified as an autoimmune and recently in kind of autoinflammatory disorders.
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