Raman scattering is well known to be a particularly weak effect, which makes it difficult to measure, especially over short time periods. Electron multiplying CCD technology has changed that to a certain extent, and is opening up areas of research that otherwise wouldn't be possible. Now entire chemical Raman maps can be made of a sample by scanning it at a microscopic level to determine its chemical composition, aided by the ability of EMCCDs to detect very small signals. Pharmaceuticals can be probed as to their chemical makeup over the surface of a tablet, while, in the life sciences, chemical interaction in cells can be studied with the confocal Raman mapping technique.
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