Multi-parallel Chiral Screening: Screening of Chiral Stationary and Mobile Phases for Method Development of Preparative Separations

摘要

A fast and automated chiral separation screening platform was developed, allowing the parallel and simultaneous testing of eight different chiral columns with a broad variety of mobile phases within a short period of time. In particular for preparative applications, this approach considerably accelerates the method development of chiral separations, leading to a significant gain of time and productivity. The increasing number of synthetic chiral drugs marketed or in development accounts for the importance of setting efficient strategies to analyse and to separate enantiomeric molecules at an early stage of drug development [1]. Among the possible strategies, enantioselective chromatography on chiral stationary phases (CSP) has proven to be an extremely powerful technique. On an analytical scale, it has become the method of choice [2], while on a preparative scale, the economic competitiveness of the chromatographic approach has now been demonstrated by several applications up to several hundreds of tons per year [3].