Enantioselective Decarboxylation of 2-Methyl-2-aminomalonate Catalyzed by (S)-2-Hydroxy-2'-(3-phenyluryl-benzyl)-1,1'-binaphthyl-3-carboxaldehyde

摘要

Aminomalonic acid (AM-H2) is a biological intermediate appearing in the conversion course of serine to glycine. Aminomalonic decarboxylases, enzymes that catalyze decarboxylation of aminomalonic acid, have been found in many living systems.' Serine hydroxymethyltransferase stereospecifically decarboxylates 2-amino-2-methyl-malonic acid (MAM-H2) to produce D-alanine. Although stereoselective decarboxylation is a century old theme, the interest on it is growing recently owing to the development of chiral technology. Chemical approaches using metal complexes and cinchonine derivatives have been developed for stereospecific decarboxylation of MAM.