A Stereoselective Synthesis of C26-C36 Fragment of Arenicolide A

摘要

Recently, arenicolides A (1) and B (2) were isolated from the large-scale fermentation of the S. arenicola strain CNR-005 and its relative stereochemical relationship except C-12, C-30, and C-31 chiral centers was proposed by H NMR, ~(13)C NMR, Mass, IR, UV, CD, chemical degradation methods. Arenicolides A (1) and B (2) are 26-membered macrolides with three conjugated dienes and nine chiral centers in the ring. There is one side chain which comprises the C-26 ~ C-36 carbon chain with five consecutive chiral centers.