Synthesis of 2-Benzylidene-7a-alkyltetrahydropyrrolizine-3,5-diones Starting from Baylis-Hillman Adducts

摘要

Recently,3-alkylidenedihydropyrrol-2-ones~(1a)and 3-alkyl-idenedihydropyrrole derivatives were synthesized starting from the Baylis-Hillman adducts of methyl acrylate and methyl vinyl ketone,respectively.These compounds were prepared by the reductive cyclization of nitroalkane derivatives,which were synthesized from the Baylis-Hillman acetate by the S_N2' reaction with primary nitroalkane,as shown in Scheme 1.