Asymmetric Synthesis of Fluoroamines from Chiral Aziridines

摘要

The fluorinated organic molecules have attracted great attentions from synthetic and medicinal chemists with wide use of various agrochemicals and pharmaceuticals.1 Their uniqueness is originated from its electronic characteristics and the small size without altering the molecular conformations of non-fluorinated compounds.1 The fluorine is the second most widely used atom in the commercial drugs following the amine.1'2 Thereby, the elaboration of fluoroamines bearing two most widely used atoms in drugs is one of the most challenging problems in drug synthesis and its development.2