Synthesis of Naringenin Amino Acid Esters as Potential CDK2 Inhibitors

摘要

The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify the degree of cell proliferation.The discovery of specific inhibitors of CDKs such as polyhydroxylated flavones has opened the way to investigation and design of antimitotic compounds.Among the polyhydroxylated flavones,flavopiridol (1,Figure 1 )has completed phase I clinical trial where it showed antitumor effect in patients with refractory neoplasms.